Major U.S. stock-indexes indexes got off to their worst start this year on Thursday after Donald Trump gave little clarity on his promises for economic growth that had powered a record-breaking rally on Wall Street for two months. The U.S. President-elect, in his first news conference on Wednesday, gave no details on tax cuts or infrastructure spending, and instead lashed out at U.S. spy agencies and news agencies over what he called a 'phony' Russia dossier. He also blasted pharmaceutical companies over high drug prices, causing health stocks to snap a six-day winning streak and a wobble in Wall Street.

Most of Dow stocks in negative area (28 of 30). Top gainer - Merck & Co., Inc. (MRK, +1.05%). Top loser - Microsoft Corporation (MSFT, -1.79%).

All S&P sectors in negative area. Top loser - Industrial goods (-1.3%).

At the moment:

Dow 19716.00 -161.00 -0.81%

S&P 500 2252.25 -18.25 -0.80%

Nasdaq 100 5002.50 -44.00 -0.87%

Oil 52.83 +0.58 +1.11%

Gold 1203.00 +6.40 +0.53%

U.S. 10yr 2.31 -0.06