Asian stocks fell, with a regional benchmark index heading for its biggest decline in three weeks, after U.S. equities retreated from record highs and a gauge of China’s non-manufacturing industries declined.

Nikkei 225 Closed

Hang Seng 22,792.99 -547.06 -2.34%

S&P/ASX 200 5,350.1 -17.81 -0.33%

Shanghai Composit Closed

Industrial & Commercial Bank of China Ltd., the nation’s biggest lender, dropped 2.5 percent in Hong Kong.

Woodside Petroleum Ltd., Australia’s second-largest oil and gas producer, fell 1.1 percent in Sydney after crude futures traded near a month low.

Celltrion Inc. jumped 6.4 percent after the South Korean arthritis drug maker said its No. 1 shareholder was in talks with potential buyers.