Major U.S. stock-indexes lower on Tuesday as investors fretted over renewed uncertainties about the Federal Reserve's plan to raise interest rates this year. International Monetary Fund Managing Director Christine Lagarde on Tuesday warned of increasing risks to global economic growth, unless there were stronger measures by policymakers. Lagarde's comments come a week after Fed Chair Janet Yellen urged caution on rate hikes, citing a shaky global economy and low oil prices. However, some Fed officials have supported an aggressive monetary policy, sparking concerns about the timing and the number of rate hikes this year.

Most of Dow stocks in negative area (25 of 30). Top looser - The Walt Disney Company (DIS, -2,38%). Top gainer - Pfizer Inc. (PFE, +2,80%).

All S&P sectors in negative area. Top looser - Utilities (-1,5%).

At the moment:

Dow 17522.00 -120.00 -0.68%

S&P 500 2038.00 -19.50 -0.95%

Nasdaq 100 4462.50 -37.75 -0.84%

Oil 35.55 -0.15 -0.42%

Gold 1230.10 +10.80 +0.89%

U.S. 10yr 1.72 -0.05