Major U.S. stock-indexes lower on Friday amid investor caution following a nuclear test by North Korea and comments by a U.S. Federal Reserve official that supported an interest rate hike. North Korea conducted its fifth and biggest nuclear test on Friday and said it had mastered the ability to mount a warhead on a ballistic missile, drawing condemnation from the United States as well as China, Pyongyang's main ally.

All Dow stocks in negative area (30 of 30). Top loser - Caterpillar Inc. (CAT, -2.11%).

All S&P sectors also in negative area. Top loser - Utilities (-2.3%).

At the moment:

Dow 18212.00 -169.00 -0.92%

S&P 500 2148.50 -22.50 -1.04%

Nasdaq 100 4746.75 -45.75 -0.95%

Oil 46.38 -1.24 -2.60%

Gold 1336.60 -5.00 -0.37%

U.S. 10yr 1.67 +0.05