Major U.S. stock-indexes fell as Apple dragged down on Friday even as investors remained wary of global economic growth worries and an impending referendum on Britain's European Union membership. Britain will vote on June 23, an event that has weaved in uncertainty across the globe, battering stocks and bond yields for the past week and spiking demand for safe-haven assets such as gold and the yen.

Most all of Dow stocks in negative area (23 of 30). Top looser - Merck & Co. Inc. (MRK, -2,80%). Top looser - Caterpillar Inc. (CAT, +0,96%).

Most of all S&P sectors in negative area. Top looser - Healthcare (-1,1%). Top gainer - Conglomerates (+1,2%).

At the moment:

Dow 17532.00 -111.00 -0.63%

S&P 500 2056.00 -14.50 -0.70%

Nasdaq 100 4357.25 -59.50 -1.35%

Oil 48.00 +1.26 +2.70%

Gold 1290.00 -8.40 -0.65%

U.S. 10yr 1.61 +0.05