Major U.S. stock-indexes lower in choppy trading late Thursday morning after two straight days of gains, pulled lower by Apple (AAPL) and healthcare stocks. The S&P healthcare index dropped as shares of Merck (MRK) and Johnson & Johnson (JNJ) booked losses. Apple fell after Barclays cut its price target. The stock was the biggest drag on Wall Street.

Almost all of Dow stocks in negative area (26 of 30). Top gainer - Caterpillar Inc. (CAT, +1.52%). Top loser - Merck & Co., Inc. (MRK, -2.23%).

Almost all S&P sectors also in negative area. Top gainer - Basic Materials (+0.3%). Top loser - Healthcare (-2.0%).

At the moment:

Dow 18085.00 -153.00 -0.84%

S&P 500 2147.25 -16.00 -0.74%

Nasdaq 100 4837.75 -30.50 -0.63%

Oil 47.78 +0.73 +1.55%

Gold 1326.40 +2.70 +0.20%

U.S. 10yr 1.56 -0.01