European stocks closed in the red Monday as equity investors got their first chance to react to President Donald Trump's inauguration speech, seen as taking a protectionist tone.

U.S. stocks closed down Monday, but off session lows of the day as investors wrestled with uncertainty over the policies of President Donald Trump and as a batch of corporate quarterly results came out mixed.

Asian shares were lacking direction early Tuesday, as the overnight decision by the U.S. to pull out of a regional trade pact, as well as increased protectionist rhetoric, have largely been priced in by the market.